Selected publications (from 175); >More than 8000 citations, h factor = 48 (Google Scholar, August 2015)

  1. Dutka, T., Hallberg, D. & Reeves, R. H. Chronic up-regulation of the SHH pathway normalizes some developmental effects of trisomy in Ts65Dn mice. Mech Dev 135, 68-80, doi:10.1016/j.mod.2014.11.004 (2015). [PDF]
  2. Ramachandran D, Mulle JG, Locke AE, Bean LJ, Rosser TC, Bose P, Dooley KJ, Cua CL, Capone GT, Reeves RH, Maslen CL, Cutler DJ, Sherman SL, Zwick ME. 2014. Contribution of Copy Number Variation to Down Syndrome-associated Atrioventricular Septal Defects. Genetics in Med. (ePub Oct 2014). [PDF]
  3. Redig, J.K., G.T. Fouad, D. Babcock, B. Reshey, E. Feingold, R.H. Reeves, C.L. Maslen. 2014. Allelic Interaction between CRELD1 and VEGFA in the Pathogenesis of Cardiac Atrioventricular Septal Defects. AIMS Genetics 1:1-19. PMC4200510 [PDF]
  4. Ackerman, C., A.E. Locke, E. Feingold, B. Reshey, K. Espana, J. Thusburg, S. Mooney, L.J.H. Bean, K.J. Dooley, C.L. Cua, R.H. Reeves, S.L. Sherman, C.L. Maslen 2012. An excess of deleterious variants in VEGF-A pathway genes in Down syndrome-associated atrioventricular septal defects. Am. J. Hum. Genet. 91:646–659. PMC3484504 [PDF]
  5. Li, H., S. Cherry, D. Klinedinst, V. DeLeon, J. Redig, B. Reshey, S.L. Sherman, C. Maslen and R.H. Reeves. 2012. Genetic modifiers predisposing to congenital heart disease in the sensitized Down syndrome population. Circ. Cardiovasc. Genet. 5(3):301-8. PMC3386785 [PDF]
  6. Das, I., Park, J.-M., Shin, J.H., Jeon, S.K., Lorenzi, H., Linden, D.J., Worley, P.F., and Reeves, R.H. (2013). Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model. Sci Transl Med. 5:201ra120 [PDF]
  7. Currier, D. G., Polk, R. C. & Reeves, R. H. in Progress in Brain Research vol. 197 Vol. In M. Dierssen and R. de la Torre Fornell (Eds.), Progress in Brain Research, Vol. 197: 223-236. (ed M. and de la Torre Fornell Dierssen, R.) (Elsevier, 2012). [PDF]
  8. Yang, A. and R.H. Reeves. 2011. Ts65Dn "Down syndrome" mice show increased survival in a complex cancer model. Cancer Res 71(10): 3573-81. PMC3096739 [PDF]
  9. Starbuck, J.M., R.H. Reeves, J.T. Richtsmeier. 2011. Morphological Integration of Soft-Tissue Facial Morphology in Down Syndrome Individuals and Siblings. Am. J. Physical 146: 560-568. PMC3258662 [PDF]
  10. Das, I. and R.H. Reeves. 2011. A crucial role for mouse models to understand and improve cognitive deficits in Down syndrome. Disease Models and Mechanisms 4:596-606. PMC3180223 [PDF]
  11. Haydar, T.F. and R.H. Reeves. 2012. Trisomy and early brain development. Trends in Neuroscience 35:81-91. PMC3273608 [PDF]
  12. Sussan T., A. Yang. F. Li, M. Ostrowski and R.H. Reeves. 2008. Trisomy protects against ApcMin-mediated tumors in mouse models of Down syndrome. Nature 451:73-5. [PDF]
  13. Olson, L.E., Roper, R.J., Sengstaken, C.L., Peterson, E.A., Aquino, V., Galdzicki, Z., Siarey, R.J., Pletnikov, M., Moran, T.H., Reeves, R.H. 2007. Trisomy for the Down syndrome “critical region” is necessary but not sufficient for brain phenotypes of trisomic mice. Hum. Molec. Genet. 16:774-82. [PDF]
  14. Hill, C.A., R.H. Reeves, J.T. Richtsmeier. 2007. Growth of the aneuploid skull. J. Anatomy 210:394-405. [PDF]
  15. Reeves, R.H. and C.C. Garner. 2007. A Year of Unprecedented Progress in Down Syndrome Basic Research. Ment. Retard. Dev. Disabil. Res. Rev. 13:215-20. [PDF]
  16. Roper, R.J.*, L.L. Baxter*, N. Saran, D. Klinedinst, P. Beachy and R.H. Reeves. 2006. Defective cerebellar response to mitogenic Hedgehog signaling in Down syndrome mice. Proc. Natl. Acad. Sci. 103(5):1452-6. *These authors contributed equally. [PDF]
  17. Roper, R.J. and R.H. Reeves. 2006. Understanding the Basis for Down syndrome Phenotypes. 2006. PLoS Genetics 2:e50. [PDF]
  18. Roper, R.J., H.K. St. John, J. Philip, A. Lawler, R.H. Reeves. 2006. Perinatal loss of Ts65Dn mice, a model Down syndrome. Genetics 172(1):437-43. [PDF]
  19. Sussan, T., M. Pletcher, Y. Murakami, and R.H. Reeves. 2005. Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth and gene expression in the non-small cell lung cancer cell line A549. Molecular Cancer 4:28. [PDF]
  20. Olson L.E., J.T. Richtsmeier, J. Leszl, and R.H. Reeves. 2004. Direct testing does not support a Chromosome 21 Critical Region as the cause of Down syndrome phenotypes when triplicated. Science 306:687-690. [PDF] [Supplemental]
  21. Olson, L.E., D. Bedja, S.J. Alvey, A.J. Cardounel, K.L. Gabrielson and R.H. Reeves. 2003. Protection from doxorubicin-induced cardiac toxicity in Mice with a null allele of Carbonyl Reductase 1 (Cbr1). Cancer Research 63: 6602-6606. [PDF]
  22. Saran, N.G., M.T. Pletcher, J.E. Natale, Y. Ching and R.H. Reeves. 2003. Global Disruption of the Cerebellar Transcriptome in a Down Syndrome Mouse Model. Hum. Mol. Genet. 12:2013-9. [PDF]
  23. Moran, T.H., Capone, G.T., Knipp, S., Davisson, M.T., Reeves, R.H. and Gearhart, J.D. 2002. The effects of piracetam on cognitive performance in a mouse model of Down's syndrome. Physiol Behav. 77:403-9. [PDF]
  24. Kuramochi, M., H. Fukuhara, T. Nobukuni, T. Kanbe, T. Maruyama, H.P. Ghosh, M. Pletcher, M. Isomura, M. Onizuka, T. Kitamura, T. Sekiya, R.H. Reeves and Y. Murakami. 2001. TSLC1 is a tumor suppressor gene in human non-small cell lung cancer. Nature Genetics 27:427-430. [PDF]
  25. Reeves, R.H., L.L. Baxter and J.T. Richtsmeier. 2001. Too much of a good thing: Mechanisms of gene action in Down syndrome. Trends in Genetics 17:83-88. [PDF]
  26. Richtsmeier, J.T., L.L. Baxter and R.H. Reeves. 2000. Parallels of craniofacial development in Down syndrome and Ts65Dn mice. Developmental Dynamics 217:137-145. [PDF]
  27. Reeves, R.H., N.G. Irving, T. Moran, A. Wohn, C. Kitt, S. Sisodia, C. Schmidt, R.T. Bronson and M.T. Davisson. 1995. A mouse model for Down Syndrome exhibits learning and behavior deficits. Nature Genetics 11:177-184. [PDF]